Proteomic analysis of Neisseria lactamica and Neisseria meningitidis outer membrane vesicle vaccine antigens. Adjuvants—a balance between toxicity and adjuvanticity. As a service to our customers we are providing this early version of the manuscript. Lactamica acts as an immune adjuvant and has the potential of being developed as a potent immune modulator derived from a non-pathogenic bacterium, which would positively affect ease of manufacturing. We have supporting evidence that the presumed native trimeric structure of Nlac PorB is maintained upon purification, suggested by the presence of high molecular weight bands in non-denaturing SDS PAGE, in a similar manner to PorB from N. Mechanism of pathogen-specific TLR4 activation in the mucosa: fimbriae, recognition receptors and adaptor protein selection. Table 1 Serum levels of Th1 and Th2 cytokine in immunized mice The sera of mice after receiving two immunizations week 4 were examined by ELISA for production of cytokines. Traces of a protein contaminant of approx.
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